The transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) has beneficial effects on spinal cord injury (SCI). However, while there are many subtypes of NPCs with different regional identities, the subtype of iPSC-derived NPCs that is most appropriate for cell therapy for SCI has not been identified. Here, we generated forebrain- and spinal cord-type NPCs from human iPSCs and grafted them onto the injured spinal cord in mice. These two types of NPCs retained their regional identities after transplantation and exhibited different graft-host interconnection properties. NPCs with spinal cord regional identity but not those with forebrain identity resulted in functional improvement in SCI mice, especially in those with mild-to-moderate lesions. This study highlights the importance of the regional identity of human iPSC-derived NPCs used in cell therapy for SCI.

中文翻译：

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通过使用人iPSC衍生的区域特异性神经祖细胞对脊髓损伤进行细胞疗法。

源自人类诱导的多能干细胞（iPSC）的神经祖细胞（NPC）的移植对脊髓损伤（SCI）具有有益的作用。但是，尽管有许多NPC的亚型具有不同的区域标识，但尚未确定最适合用于SCI细胞疗法的iPSC衍生NPC的亚型。在这里，我们从人iPSC生成了前脑型和脊髓型NPC，并将它们移植到了小鼠受伤的脊髓上。这两种类型的NPC在移植后仍保留其区域身份，并表现出不同的移植物-宿主互连特性。具有脊髓区域同一性的NPC但具有前脑同一性的NPC导致SCI小鼠的功能改善，尤其是那些具有轻度至中度病变的小鼠。