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Needle-free delivery of fluids from compact laser-based jet injector.
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-09-03 , DOI: 10.1039/d0lc00646g Jan Krizek 1 , Frédéric De Goumoëns , Paul Delrot , Christophe Moser
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-09-03 , DOI: 10.1039/d0lc00646g Jan Krizek 1 , Frédéric De Goumoëns , Paul Delrot , Christophe Moser
Affiliation
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Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Due to bulky actuation mechanisms, they are limited to body areas that are easy to reach such as skin. Here, we demonstrate a thin and long liquid delivery system (e.g. flexible and 30 cm long with 1.2 mm outer diameter) compatible with minimally invasive surgical procedures. The actuation mechanism is based on optical cavitation in a capillary nozzle where a laser pulse is delivered via a multimode optical fibre. We show good controllability of the jet speed by varying the actuation laser fluence. The generated jets can successfully penetrate into a 1% agarose gel which is representative of the mechanical properties of several soft body tissues. We further observe that when the system is used in a low laser energy regime (<60 μJ), the ejection is in the form of the single droplet which is promising for fluid delivery with high volume precision or drop-on-demand inkjet printing. The jet injection system we propose has the potential to deliver heat-sensitive therapeutics as we show processing of biomolecules without altering their functionality.
中文翻译：
紧凑型基于激光的喷射注射器无针输送流体。
为了避免使用针头，已经研究并开发了用于透皮药物输送的喷射注射装置。由于笨重的致动机制，它们仅限于容易触及的身体区域，例如皮肤。在这里，我们展示了一种薄而长的输液系统（例如，柔性且30厘米长，外径为1.2毫米），可与微创手术程序兼容。该致动机制基于毛细管喷嘴中的光学空化，在该喷嘴中，激光脉冲通过多模光纤。通过改变致动激光能量密度，我们显示了喷射速度的良好可控性。产生的射流可以成功渗透到1％的琼脂糖凝胶中，该凝胶代表了几种软组织的机械性能。我们进一步观察到，当系统在低激光能量范围（<60μJ）中使用时，喷射形式为单个液滴，这有望以高体积精度或按需喷墨打印进行流体输送。我们提出的喷射注射系统有潜力提供对热敏感的治疗剂，因为我们展示了生物分子的加工过程，而不会改变其功能。
更新日期：2020-10-13
中文翻译：
紧凑型基于激光的喷射注射器无针输送流体。
为了避免使用针头，已经研究并开发了用于透皮药物输送的喷射注射装置。由于笨重的致动机制，它们仅限于容易触及的身体区域，例如皮肤。在这里，我们展示了一种薄而长的输液系统（例如，柔性且30厘米长，外径为1.2毫米），可与微创手术程序兼容。该致动机制基于毛细管喷嘴中的光学空化，在该喷嘴中，激光脉冲通过多模光纤。通过改变致动激光能量密度，我们显示了喷射速度的良好可控性。产生的射流可以成功渗透到1％的琼脂糖凝胶中，该凝胶代表了几种软组织的机械性能。我们进一步观察到，当系统在低激光能量范围（<60μJ）中使用时，喷射形式为单个液滴，这有望以高体积精度或按需喷墨打印进行流体输送。我们提出的喷射注射系统有潜力提供对热敏感的治疗剂，因为我们展示了生物分子的加工过程，而不会改变其功能。
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