In persons with multiple sclerosis (PwMS), the neutrophil-to-lymphocyte ratio (NLR) is associated with disability status, symptomatology and disease activity. High-intensity interval training (HIIT) improves many symptoms in PwMS and may positively influence disease progression. Here, we present results from a randomized controlled trial during inpatient rehabilitation on immediate (single bout) and training (3-week intervention) effects of HIIT versus moderate continuous training on NLR and related cellular inflammation markers. Only HIIT reduced the NLR over the 3-week intervention period. These training effects might be due to repetitive inflammatory states with compensatory anti-inflammatory counterbalancing after each HIIT session.

中文翻译：

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高强度间歇训练可降低住院康复期间多发性硬化症患者的中性粒细胞与淋巴细胞的比率

在多发性硬化症 (PwMS) 患者中，中性粒细胞与淋巴细胞的比率 (NLR) 与残疾状态、症状和疾病活动相关。高强度间歇训练 (HIIT) 可改善 PwMS 的许多症状，并可能对疾病进展产生积极影响。在这里，我们展示了住院康复期间一项随机对照试验的结果，即 HIIT 与中等持续训练对 NLR 和相关细胞炎症标志物的即时（单次）和训练（3 周干预）效果。在 3 周的干预期间，只有 HIIT 降低了 NLR。这些训练效果可能是由于每次 HIIT 课程后重复的炎症状态和补偿性抗炎平衡。