N-Alkenoxypyridinium salts were found to be highly active electrophilic reagents that could be used to activate the C–N bond of amides. Both aromatic amides and aliphatic amides could be transformed into the corresponding β-oxo esters with good yields via the combined use of N-alkenoxypyridinium salts and water. The methodology proceeds under mild reaction conditions and is tolerant of various functional groups in both reaction partners.

中文翻译：

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一种通过N-烷氧基吡啶鎓盐作为活化剂和H2O作为亲核试剂的酰胺转化为β-氧代酯的策略。

N-烯氧基吡啶鎓盐被发现是高度活性的亲电试剂，可用于激活酰胺的C–N键。通过结合使用N-烯氧基吡啶鎓盐和水，芳族酰胺和脂族酰胺都可以良好的产率转化为相应的β-氧代酯。该方法在温和的反应条件下进行，并且可以耐受两个反应伙伴中的各种官能团。