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Surface-Directed Disparity in Self-Assembled Structures of Small-Peptide l-Glutathione on Gold and Silver Nanoparticles.
Langmuir ( IF 3.7 ) Pub Date : 2020-09-03 , DOI: 10.1021/acs.langmuir.0c01527 Suranjana Chakrabarty 1 , Swagata Maity 1 , Darshana Yazhini 1 , Anup Ghosh 1
Langmuir ( IF 3.7 ) Pub Date : 2020-09-03 , DOI: 10.1021/acs.langmuir.0c01527 Suranjana Chakrabarty 1 , Swagata Maity 1 , Darshana Yazhini 1 , Anup Ghosh 1
Affiliation
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Despite the key roles of l-glutathiones (GSHs) inbiology and nano-biotechnology, understanding their labile structures and hydrogen bond interactions with nanoparticles has posed a critical challenge to the scientific community. The structural conformation of GSH as a capping layer on gold nanoparticle (AuNP) and silver nanoparticle (AgNP) surfaces is investigated. In this report, we attempt to explore the material-dependent interaction of GSH with different spherical nanoparticle surfaces by employing Fourier transform infrared (FTIR) spectroscopy. The infrared signal of amide I of GSH is studied as a function of different materials’ spherical nanoparticles with comparable size. We revealed the β-sheet secondary structure of GSH on AgNPs and the random structure on AuNPs even though both the nanoparticles have comparable shapes and sizes and belong to the same group of the periodic table. The GSH is firmly anchored on the gold and silver surface via the thiol of the cys part. However, our experimental data designate a further interaction with the AgNP surface via the carboxylic acid group of the gly- and glu- end of the molecule. It is observed that enhancement of IR absorption of amide I of GSH is pronounced by a factor of 10 on AuNP but, in contrast, on the same-sized AgNP, the suppression is perceived by a factor of 2, even though both are plasmonic materials with respect to free GSH. This study can be used as a point of reference for understanding the structural conformation of the capping layer on nanoparticle surfaces as well as surface enhancement of the IR absorption of amide I. We would like to emphasize that molecular self-assembly on the nanoparticle surfaces is definitely of very broad interest for chemists working in nearly any subdiscipline, spanning from the nanoparticle-based medicine to surface-enhanced spectroscopy to heterogeneous catalysis, etc.
中文翻译：
金和银纳米粒子上小肽l-谷胱甘肽自组装结构中的表面定向差异。
尽管l扮演着关键角色-谷胱甘肽（GSHs）生物学和纳米生物技术，了解它们的不稳定结构以及与纳米颗粒的氢键相互作用已对科学界提出了严峻的挑战。研究了GSH作为金纳米颗粒（AuNP）和银纳米颗粒（AgNP）表面覆盖层的结构构象。在此报告中，我们尝试通过傅立叶变换红外（FTIR）光谱探索GSH与不同球形纳米颗粒表面的材料依赖性相互作用。研究了GSH酰胺I的红外信号，它是具有不同尺寸的不同材料的球形纳米颗粒的函数。我们揭示了AgNPs上GSH的β-折叠二级结构和AuNPs上的随机结构，即使这两种纳米颗粒具有可比较的形状和大小并且属于元素周期表的同一组。GSH通过cys部分的硫醇牢固地锚定在金和银的表面上。然而，我们的实验数据表明通过分子的糖基和糖基端的羧酸基团与AgNP表面的进一步相互作用。观察到，AuNP对GSH酰胺I的IR吸收的增强作用是10，但是相比之下，在相同大小的AgNP上，抑制作用的感觉是2，即使两者都是等离子体材料关于免费的GSH。
更新日期：2020-09-29
中文翻译：
金和银纳米粒子上小肽l-谷胱甘肽自组装结构中的表面定向差异。
尽管l扮演着关键角色-谷胱甘肽（GSHs）生物学和纳米生物技术，了解它们的不稳定结构以及与纳米颗粒的氢键相互作用已对科学界提出了严峻的挑战。研究了GSH作为金纳米颗粒（AuNP）和银纳米颗粒（AgNP）表面覆盖层的结构构象。在此报告中，我们尝试通过傅立叶变换红外（FTIR）光谱探索GSH与不同球形纳米颗粒表面的材料依赖性相互作用。研究了GSH酰胺I的红外信号，它是具有不同尺寸的不同材料的球形纳米颗粒的函数。我们揭示了AgNPs上GSH的β-折叠二级结构和AuNPs上的随机结构，即使这两种纳米颗粒具有可比较的形状和大小并且属于元素周期表的同一组。GSH通过cys部分的硫醇牢固地锚定在金和银的表面上。然而，我们的实验数据表明通过分子的糖基和糖基端的羧酸基团与AgNP表面的进一步相互作用。观察到，AuNP对GSH酰胺I的IR吸收的增强作用是10，但是相比之下，在相同大小的AgNP上，抑制作用的感觉是2，即使两者都是等离子体材料关于免费的GSH。
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