Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by Streptomyces fumigatiscleroticus HDN10255.,Journal of Natural Products

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Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by Streptomyces fumigatiscleroticus HDN10255.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-09-03 , DOI: 10.1021/acs.jnatprod.0c00805
Junxiao Wang ₁ , Haotian Wang _{1,

2} , Chunxiao Sun ₁ , Fenge Li ₁ , Yingqiang Wu ₁ , Guojian Zhang _{1,

3} , Qianqun Gu ₁ , Tianjiao Zhu ₁ , Dehai Li _{1,

3} , Qian Che ₁

Affiliation

Four new tetrahydroanthracene derivatives (1, 3–5) and a known antibiotic, A-39183A (2), were discovered from the marine-sponge-derived actinomycete Streptomyces fumigatiscleroticus HDN10255. Their structures including absolute configurations were elucidated based upon MS and NMR spectroscopic data, ECD calculations, and biogenetic considerations. Compounds 2 and 4 showed considerable cytotoxicity with the best IC₅₀ value of 1.8 μM against HeLa cells.

中文翻译：

烟曲霉 HDN10255 产生的二聚四氢蒽区域异构体及其单体前体。

从海洋海绵衍生的放线菌烟熏链霉菌HDN10255中发现了四种新的四氢蒽衍生物 ( 1 , 3 – 5 ) 和一种已知的抗生素 A-39183A ( 2 ) 。基于 MS 和 NMR 光谱数据、ECD 计算和生物遗传考虑阐明了它们的结构，包括绝对构型。化合物2和4显示出相当大的细胞毒性，对 HeLa 细胞的最佳 IC ₅₀值为 1.8 μM。

更新日期：2020-09-25

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