Metabolic reprogramming has been recognized as one of the 10 new hallmarks of cancer cells [1]. Increased glycolysis (Warburg effect) under normoxic conditions and glutamine metabolism has been well recognized as the main characteristics of human malignancies [2]. Cumulative evidence supports the concept that dysregulation of lipid metabolism is also one of the key metabolic markers of cancer cells [3]. Cancer cells with highly proliferating rate can obtain more lipids by enhancing lipid uptake, lipolysis, and de novo fatty acid synthesis. Studies have revealed the importance of lipid metabolic reprogramming in carcinogenesis [4]. Lipid metabolism is tightly related to the proliferation, invasion, migration, radiosensitivity, and chemosensitivity of several tumors, including lung and breast cancers [4,5].

中文翻译：

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甲状腺乳头状癌中与脂质代谢相关的基因表达相关的分子亚型的特征。

代谢重编程已被认为是癌细胞的10个新标志之一[1]。在常氧条件下和谷氨酰胺代谢下增加的糖酵解（Warburg效应）已被公认为是人类恶性肿瘤的主要特征[2]。累积证据支持脂质代谢失调也是癌细胞关键代谢标志之一的概念[3]。具有高增殖率的癌细胞可以通过增强脂质摄取，脂解和从头脂肪酸合成来获得更多脂质。研究表明脂质代谢重编程在致癌中的重要性[4]。脂质代谢与包括肺癌和乳腺癌在内的多种肿瘤的增殖，侵袭，迁移，放射敏感性和化学敏感性紧密相关[4,5]。