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Pedigrees and Perpetrators: Uses of DNA and Genealogy in Forensic Investigations.
Annual Review of Genomics and Human Genetics ( IF 7.7 ) Pub Date : 2020-09-01 , DOI: 10.1146/annurev-genom-111819-084213
Sara H Katsanis 1, 2
Affiliation  

In the past few years, cases with DNA evidence that could not be solved with direct matches in DNA databases have benefited from comparing single-nucleotide polymorphism data with private and public genomic databases. Using a combination of genome comparisons and traditional genealogical research, investigators can triangulate distant relatives to the contributor of DNA data from a crime scene, ultimately identifying perpetrators of violent crimes. This approach has also been successful in identifying unknown deceased persons and perpetrators of lesser crimes. Such advances are bringing into focus ethical questions on how much access to DNA databases should be granted to law enforcement and how best to empower public genome contributors with control over their data. The necessary policies will take time to develop but can be informed by reflection on the familial searching policies developed for searches of the federal DNA database and considerations of the anonymity and privacy interests of civilians.

中文翻译:


家谱和肇事者:DNA和家谱在法医调查中的用途。

在过去的几年中,通过将单核苷酸多态性数据与私人和公共基因组数据库进行比较,受益于DNA证据无法通过DNA数据库直接匹配解决的案件。通过将基因组比较和传统的族谱研究相结合,研究人员可以将远方的亲戚与犯罪现场的DNA数据贡献者进行三角关系,从而最终确定暴力犯罪的肇事者。这种方法还成功地查明了不知名的死者和轻罪的肇事者。这些进展使道德问题成为焦点问题,这些问题涉及应授予执法部门多少DNA数据库访问权限,以及如何最好地增强公共基因组贡献者对其数据的控制权。

更新日期:2020-09-03
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