Objectives: This work investigated the effect of acetogenin-rich fraction of Annona muricata leaves (AFAL) on antioxidant status and some markers of benign prostatic hyperplasia (BPH) in rats.

Methods: BPH was experimentally induced in the rats by subcutaneous injection of testosterone propionate (TP, 3 mg/kg) for 28 consecutive days. The rats were administered orally different doses of AFAL (100 and 200 mg/kg) for 7 days. Prostate-specific antigen (PSA), prostate weight, relative prostate weight, prostate protein content and oxidative stress indices of the rats were evaluated.

Results: It was observed that 200 mg/kg AFAL significantly reduced the PSA level, mean prostate weights and mean relative prostate weights of the test rats compared to the TP group, and the values were not significantly different from the normal control and group treated with a standard drug. The plant extract also significantly enhanced the antioxidant capacity of the test rats which were evidently compromised in the group that received the exogenous hormone alone. Histopathology of the prostate showed a marked recovery for the test rats after treatment with AFAL.

Conclusion: Oral administration of acetogenin-rich fraction of Annona muricata leaves ameliorated TP-induced BPH in rats and significantly enhanced the antioxidant capacity of the rats.

目的：这项工作研究了番荔枝叶 (AFAL) 中富含乙酸元的部分对大鼠抗氧化状态和良性前列腺增生 (BPH) 的一些标志物的影响。

方法：通过连续28天皮下注射丙酸睾酮（TP，3 mg/kg）在大鼠中实验诱导BPH。大鼠口服不同剂量的 AFAL（100 和 200 毫克/千克），持续 7 天。评估大鼠的前列腺特异性抗原(PSA)、前列腺重量、相对前列腺重量、前列腺蛋白含量和氧化应激指数。

结果：观察到，与TP组相比，200 mg/kg AFAL显着降低了受试大鼠的PSA水平、平均前列腺重量和平均相对前列腺重量，且与正常对照组和治疗组无显着差异。一种标准药物。植物提取物还显着增强了测试大鼠的抗氧化能力，这些大鼠在单独接受外源激素的组中明显受损。前列腺的组织病理学显示，在用 AFAL 治疗后，测试大鼠的显着恢复。

结论：番荔枝叶中富含乙酰苷元的部分口服给药可改善 TP 诱导的大鼠 BPH，并显着增强大鼠的抗氧化能力。