Changes in cardiomyocyte metabolism have been heavily implicated in cardiac injury and heart failure (HF). However, there is emerging evidence that metabolism in non-myocyte populations, including cardiac fibroblasts, immune cells, and endothelial cells, plays an important role in cardiac remodeling and adaptation to injury. Here, we discuss recent advances and insights into non-myocyte metabolism in the healthy and injured heart. Metabolic switching from mitochondrial oxidative phosphorylation to glycolysis is critical for immune cell (macrophage and T lymphocyte) and fibroblast phenotypic switching in the inflamed and fibrotic heart. On the other hand, cardiac endothelial cells are heavily reliant on glycolytic metabolism, and thus impairments in glycolytic metabolism underlie endothelial cell dysfunction. Finally, we review current and ongoing metabolic therapies for HF and the potential implications for non-myocyte metabolism.

中文翻译：

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免疫代谢和非肌细胞代谢在心脏重构和损伤中的新作用。

心肌细胞代谢的变化与心脏损伤和心力衰竭 (HF) 密切相关。然而，有新的证据表明非心肌细胞群的代谢，包括心脏成纤维细胞、免疫细胞和内皮细胞，在心脏重塑和对损伤的适应中起着重要作用。在这里，我们讨论了健康和受伤心脏中非肌细胞代谢的最新进展和见解。从线粒体氧化磷酸化到糖酵解的代谢转换对于炎症和纤维化心脏中的免疫细胞（巨噬细胞和 T 淋巴细胞）和成纤维细胞表型转换至关重要。另一方面，心脏内皮细胞严重依赖糖酵解代谢，因此糖酵解代谢受损是内皮细胞功能障碍的基础。最后，