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Central and Peripheral Modulation of Exercise Pressor Reflex Sensitivity After Non-Fatiguing Work.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology ( IF 2.2 ) Pub Date : 2020-09-02 , DOI: 10.1152/ajpregu.00127.2020
Jon Stavres 1 , J Carter Luck 1 , Guillaume P Ducrocq 1 , Aimee E Cauffman 1 , Samuel Pai 1 , Lawrence I Sinoway 1
Affiliation  

Autonomic blood pressure control is fundamentally altered during a single bout of exercise, as evidenced by the downward resetting of the baroreflex following exercise (post exercise hypotension). However, it is unclear if an acute bout of exercise is also associated with a change in the sensitivity of the exercise pressor response to a controlled stimulus, such as a static contraction. This study tested the hypothesis that the blood pressure response to a controlled static contraction would be attenuated after unilateral cycling of the contralateral (opposite) leg, but preserved after cycling of the ipsilateral (same) leg. To test this, the blood pressure response to 90 sec of isometric plantar flexion (50% MVC) was compared before and after 20 min of contralateral and ipsilateral single leg cycling at 20% Vo2peak and rest (control) in 10 healthy subjects (three males, seven females). The mean arterial pressure response was significantly attenuated after contralateral single leg cycling (+9.8±7.5% ∆ mmHg vs. +6.7±6.6% ∆ mmHg pre and post exercise, respectively, P=0.04) and rest (+9.0±7.5% ∆ mmHg vs. +6.6±5.2% ∆ mmHg pre and post exercise, respectively, P=0.03). In contrast, the pressor response non-significantly increased following ipsilateral single leg cycling (+5.5±5.2% ∆ mmHg vs. +8.9±7.2% ∆ mmHg pre and post exercise, respectively, P=0.08). The heart rate, leg blood flow, and leg conductance responses to plantar flexion were not affected by any condition (P≥0.12). These results are consistent with the notion that peripheral, but not central mechanisms promote exercise pressor reflex sensitivity after exercise.

中文翻译:

非疲劳工作后运动加压反射敏感性的中枢和外周调节。

自主血压控制在一次运动中发生了根本性的改变,运动后压力反射的向下重置(运动后低血压)证明了这一点。然而,尚不清楚剧烈运动是否也与运动加压反应对受控刺激(例如静态收缩)的敏感性发生变化有关。该研究检验了以下假设:在对侧(对侧)腿进行单侧循环后,对受控静态收缩的血压反应会减弱,但在同侧(同侧)腿循环后保持不变。为了测试这一点,在 20% Vo 2peak的对侧和同侧单腿骑行 20 分钟之前和之后,比较了对 90 秒等长足底屈曲 (50% MVC) 的血压反应并在 10 名健康受试者(三名男性,七名女性)中休息(对照)。在对侧单腿骑自行车(+9.8±7.5% ∆ mmHg vs. +6.7±6.6% ∆ mmHg 运动前后,P=0.04)和休息(+9.0±7.5% ∆ mmHg)后,平均动脉压反应显着减弱mmHg 与 +6.6±5.2% ∆ mmHg 分别在运动前和运动后,P=0.03)。相比之下,同侧单腿骑行后升压反应无显着增加(+5.5±5.2% ∆ mmHg vs. +8.9±7.2% ∆ mmHg 运动前后,P=0.08)。心率、腿部血流量和足底屈曲的腿部电导反应不受任何条件的影响(P≥0.12)。这些结果与外周而非中枢机制促进运动后运动升压反射敏感性的观点一致。
更新日期:2020-09-03
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