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Multi‐drug resistant, biofilm producing high‐risk clonal lineage of Klebsiella in companion and household animals
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-09-11 , DOI: 10.1111/lam.13381 A Banerjee 1 , K Batabyal 1 , A D Singh 2 , S N Joardar 1 , S Dey 1 , D P Isore 1 , T K Sar 3 , T K Dutta 4 , S Bandyopadhyay 5 , I Samanta 1
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-09-11 , DOI: 10.1111/lam.13381 A Banerjee 1 , K Batabyal 1 , A D Singh 2 , S N Joardar 1 , S Dey 1 , D P Isore 1 , T K Sar 3 , T K Dutta 4 , S Bandyopadhyay 5 , I Samanta 1
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Antimicrobial resistance is a global emergency which needs one health approach to address. The present study was conducted to detect the prevalence of beta‐lactamase and biofilm‐producing Klebsiella strains in rectal swabs (n = 624) collected from healthy dogs, cats, sheep and goats reared as companion or household animals in India. The dogs and cats were frequently exposed to third‐ or fourth‐generation cephalosporins for therapy. The sheep and goats were occasionally exposed to antibiotics and had environmental exposure. Phenotypical ESBL (n = 93) and ACBL (n = 88)‐producing Klebsiella were isolated significantly more (P < 0·05) from companion animals than household animals. Majority of the Klebsiella possessed blaCTX‐M‐15. The sequences blaCTX‐M‐15.2, blaCTX‐M‐197 and blaCTX‐M‐225 are reported first time from the companion animals. All ACBL‐producing isolates possessed blaAmpC. The present study detected 65·8% of Klebsiella strains as biofilm producers possessing the studied biofilm associated genes. The isolates showed phenotypical resistance against chloramphenicol, tetracycline, doxycycline, co‐trimoxazole, ampicillin, cefotaxime/clavulanic acid. The present study showed that companion and household animals (dogs, cats, sheep, goats) may act as a carrier of ESBL/biofilm‐producing, multi‐drug resistant, high‐risk clonal lineage of Klebsiella.
中文翻译：
在伴侣动物和家养动物中产生多重耐药性、生物膜的克雷伯氏菌高危克隆谱系
抗菌素耐药性是一个全球紧急情况，需要一种健康方法来解决。本研究旨在检测从印度作为伴侣或家庭动物饲养的健康狗、猫、绵羊和山羊的直肠拭子（n = 624）中产β-内酰胺酶和生物膜克雷伯氏菌菌株的流行率。狗和猫经常接触第三代或第四代头孢菌素进行治疗。绵羊和山羊偶尔会接触抗生素并接触环境。与家养动物相比，从伴侣动物中分离出表型 ESBL（n = 93）和 ACBL（n = 88）的克雷伯菌明显更多（P < 0·05）。大多数克雷伯氏菌具有 blaCTX-M-15。blaCTX-M-15.2、blaCTX-M-197和blaCTX-M-225序列是首次从伴侣动物中报道。所有产生 ACBL 的分离株都具有 blaAmpC。本研究检测到 65·8% 的克雷伯菌菌株作为生物膜生产者拥有所研究的生物膜相关基因。分离株对氯霉素、四环素、强力霉素、复方新诺明、氨苄西林、头孢噻肟/克拉维酸表现出表型耐药性。本研究表明，伴侣动物和家养动物（狗、猫、绵羊、山羊）可能是产 ESBL/生物膜、多重耐药、高危克雷伯菌克隆谱系的载体。
更新日期：2020-09-11
中文翻译：
在伴侣动物和家养动物中产生多重耐药性、生物膜的克雷伯氏菌高危克隆谱系
抗菌素耐药性是一个全球紧急情况，需要一种健康方法来解决。本研究旨在检测从印度作为伴侣或家庭动物饲养的健康狗、猫、绵羊和山羊的直肠拭子（n = 624）中产β-内酰胺酶和生物膜克雷伯氏菌菌株的流行率。狗和猫经常接触第三代或第四代头孢菌素进行治疗。绵羊和山羊偶尔会接触抗生素并接触环境。与家养动物相比，从伴侣动物中分离出表型 ESBL（n = 93）和 ACBL（n = 88）的克雷伯菌明显更多（P < 0·05）。大多数克雷伯氏菌具有 blaCTX-M-15。blaCTX-M-15.2、blaCTX-M-197和blaCTX-M-225序列是首次从伴侣动物中报道。所有产生 ACBL 的分离株都具有 blaAmpC。本研究检测到 65·8% 的克雷伯菌菌株作为生物膜生产者拥有所研究的生物膜相关基因。分离株对氯霉素、四环素、强力霉素、复方新诺明、氨苄西林、头孢噻肟/克拉维酸表现出表型耐药性。本研究表明，伴侣动物和家养动物（狗、猫、绵羊、山羊）可能是产 ESBL/生物膜、多重耐药、高危克雷伯菌克隆谱系的载体。
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