Our colorful cover features an immunofluorescence assay from liver tissues of the humanized mice infected with HCV. The liver tissues were stained with anti‐CD19 antibody, anti‐IL‐10 antibody and DAPI. The image is taken from Liu et al. (pp. 1350–1361), where the authors show that HCV induced IL‐10 producing B (B10) cells in the liver tissues. Moreover, HCV‐induced B10 cells were enriched in CD19^hi and CD1d^hiCD5⁺ cell populations. HCV predominantly triggered the TLR2‐MyD88‐NF‐κB and AP‐1 signaling pathways to drive IL‐10 production by B cells. Targeting B10 cells via neutralization of IL‐10 might offer a novel strategy to enhance anti‐HCV immunotherapy. The original mage was digitally modified for the cover.

中文翻译：

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封面故事：Eur。J.免疫。9'20

我们的彩色封面具有从被HCV感染的人源化小鼠肝脏组织中进行的免疫荧光测定的功能。肝组织用抗CD19抗体，抗IL-10抗体和DAPI染色。该图像取自Liu等。（pp。1350–1361），作者表明HCV诱导肝组织中产生IL-10的B（B10）细胞。此外，HCV诱导的B10细胞富含CD19 ^hi和CD1d ^hi CD5 ⁺细胞群。HCV主要触发TLR2-MyD88-NF-κB和AP-1信号通路来驱动B细胞产生IL-10。通过中和IL-10靶向B10细胞可能提供增强抗HCV免疫疗法的新策略。原始的法师被数字修改为封面。