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Fe3+-Driven Assembly of Catalase-Like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumor.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-09-03 , DOI: 10.1002/anie.202010005 Yongxin Li 1 , Pan Sun 2 , Luyang Zhao 3 , Xuehai Yan 3 , Dennis K P Ng 4 , Pui-Chi Lo 1
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-09-03 , DOI: 10.1002/anie.202010005 Yongxin Li 1 , Pan Sun 2 , Luyang Zhao 3 , Xuehai Yan 3 , Dennis K P Ng 4 , Pui-Chi Lo 1
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A facile approach to assemble catalase‐like photosensitizing nanozymes with a self‐oxygen‐supplying ability was developed. The process involved Fe3+‐driven self‐assembly of fluorenylmethyloxycarbonyl (Fmoc)‐protected amino acids. By adding a zinc(II) phthalocyanine‐based photosensitizer (ZnPc) and the hypoxia‐inducible factor 1 (HIF‐1) inhibitor acriflavine (ACF) during the Fe3+‐promoted self‐assembly of Fmoc‐protected cysteine (Fmoc‐Cys), the nanovesicles Fmoc‐Cys/Fe@Pc and Fmoc‐Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe3+ could catalyze the transformation of H2O2 enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc‐Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc‐Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.
中文翻译：
Fe3 +驱动的过氧化氢酶样超分子光敏纳米酶，用于抗缺氧肿瘤。
开发了一种简便的方法来组装具有自氧供应能力的过氧化氢酶样光敏纳米酶。该过程涉及Fe 3+驱动的芴基甲氧羰基（Fmoc）保护的氨基酸的自组装。在Fe 3+促进的Fmoc保护的半胱氨酸（Fmoc-Cys）自组装过程中，通过添加基于酞菁锌的锌（II）光敏剂（ZnPc）和缺氧诱导因子1（HIF-1）抑制剂a黄素（ACF）），制备了纳米囊泡Fmoc-Cys / Fe @ Pc和Fmoc-Cys / Fe @ Pc / ACF，可以在细胞内拆解。释放的Fe 3+可以催化H 2 O 2的转化富集在癌细胞中的氧气可以有效地富集，从而改善缺氧条件并促进释放的ZnPc的光敏活性。与Fmoc-Cys / Fe @ Pc相比，Fmoc-Cys / Fe @ Pc / ACF除具有其他治疗成分外，还表现出更高的体外和体内光动力学活性，证明了ZnPc和ACF的协同作用。
更新日期：2020-09-03
中文翻译：
Fe3 +驱动的过氧化氢酶样超分子光敏纳米酶，用于抗缺氧肿瘤。
开发了一种简便的方法来组装具有自氧供应能力的过氧化氢酶样光敏纳米酶。该过程涉及Fe 3+驱动的芴基甲氧羰基（Fmoc）保护的氨基酸的自组装。在Fe 3+促进的Fmoc保护的半胱氨酸（Fmoc-Cys）自组装过程中，通过添加基于酞菁锌的锌（II）光敏剂（ZnPc）和缺氧诱导因子1（HIF-1）抑制剂a黄素（ACF）），制备了纳米囊泡Fmoc-Cys / Fe @ Pc和Fmoc-Cys / Fe @ Pc / ACF，可以在细胞内拆解。释放的Fe 3+可以催化H 2 O 2的转化富集在癌细胞中的氧气可以有效地富集，从而改善缺氧条件并促进释放的ZnPc的光敏活性。与Fmoc-Cys / Fe @ Pc相比，Fmoc-Cys / Fe @ Pc / ACF除具有其他治疗成分外，还表现出更高的体外和体内光动力学活性，证明了ZnPc和ACF的协同作用。
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