Carbon tetrachloride (CCl₄) is a Potential nephrotoxin that causes severe and prolonged chemical toxicity. Investigations have been accomplished on numerous species of genus Artemisia, but the plant Artemisia brevifolia has hardly been used in this respect. The present study was considered to ascertain the effects of “Artemisia brevifolia plant extract” against CCl₄ prompted nephrotoxicity in male albino rats. Forty-eight male albino rats were allocated into eight groups containing 6 rats in each. Group I was the control group. Group II was given dimethyl sulfoxide (DMSO) (1 ml/kg) orally. Group III was treated with dissolved CCl₄ in olive oil (1 ml/kg). Group IV was given CCl₄ + Silymarine. Group V and VI were administered with Artemisia brevifolia extract (150 and 300 mg/kg respectively) + CCl₄. Group VII and VIII were provided with only 150 and 300 mg/kg extract of Artemisia brevifolia respectively. Results displayed that CCl₄ administration significantly (p < 0.05) reduced the activity of antioxidant enzymes like catalase (CAT), peroxidase (POD), Superoxide dismutase (SOD), glutathione (GSH), glutathione reductase (GSR), glutathione-S-transferase (GST), albumin, creatinine clearance and Comet parameters (head length, % in head) while increased the level of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide (H₂O₂), urea, creatinine, urobilinogen, urinary proteins and comet parameters (number of comets, tail length, comet length, tail moment, % in tail). The administration of Artemisia brevifolia significantly (p < 0.05) improved the histopathology of renal tissues. The results revealed that Artemisia brevifolia has protective consequences against CCl₄ induced kidney damage.

四氯化碳（CCl ₄）是潜在的肾毒素，可引起严重和长期的化学毒性。已经对多种蒿属物种进行了研究，但是在这方面几乎没有使用短叶蒿属植物。本研究被认为是确定“小叶蒿提取物”对CCl ₄促成的雄性白化病大鼠肾毒性的作用。将四十八只白化病雄性大鼠分为八组，每组六只。第一组是对照组。第II组口服二甲基亚砜（DMSO）（1 ml / kg）。III组用溶于橄榄油的CCl ₄（1 ml / kg）处理。第四组获得CCl₄  +水飞蓟素。第五组和第六组用短叶蒿提取物（分别为150和300 mg / kg）+ CCl ₄给药。第七和第八组分别仅提供了150和300 mg / kg的短叶蒿提取物。结果显示，施用CCl ₄显着（p <0.05）降低了抗氧化酶的活性，如过氧化氢酶（CAT），过氧化物酶（POD），超氧化物歧化酶（SOD），谷胱甘肽（GSH），谷胱甘肽还原酶（GSR），谷胱甘肽-S-转移酶（GST），白蛋白，肌酐清除率和彗星参数（头长，头上的％），同时增加了硫代巴比妥酸反应性物质（TBARS），过氧化氢（H ₂ O _{2）的水平}），尿素，肌酐，尿胆原原，尿蛋白和彗星参数（彗星数，尾巴长度，彗星长度，尾矩，尾巴百分数）。短叶蒿的给药显着（p <0.05）改善了肾组织的组织病理学。结果表明，短叶蒿对CCl ₄引起的肾脏损害具有保护作用。