Surface-enhanced Raman spectroscopy based on thioglycolic acid (TGA) functionalized silver-coated gold nanoparticles (Au@Ag-TGANPs) was developed for the facile screening of thiabendazole (TBZ) and ferbam (0.025–10 ppm) in liquid milk for the first time. Results showed that silver-coated gold nanoparticles (Au@AgNPs) with a core size of 32 nm and a shell thickness of 5 nm was successfully modified with 3 nm TGA. The sensitive Au@Ag-TGANPs could enhance TBZ and ferbam signals by factors of 6.4 × 10⁴ and 9.8 × 10⁴, respectively, and achieved the detection of TBZ and ferbam with limits of detection of 0.12 and 0.003 ppm, R² of 0.988 and 0.9821, percent recoveries of 88–103% and of 87.2–103.5%, and relative standard deviations of 4.1–9.2% and 3.5–8.3%, respectively. The current simple and green method could thus be used to detect other unsafe chemicals in future studies.

基于巯基乙酸（TGA）功能化的银包金纳米颗粒（Au @ Ag-TGANPs）的表面增强拉曼光谱仪被开发用于快速筛选液态牛奶中的噻菌灵（TBZ）和富巴姆（0.025-10 ppm）。时间。结果表明，用3 nm TGA成功修饰了核尺寸为32 nm，壳厚度为5 nm的涂银金纳米颗粒（Au @ AgNPs）。敏感的Au @ Ag-TGANPs可以分别将TBZ和ferbam信号增强6.4×10 ⁴和9.8×10 ⁴倍，并实现了TBZ和ferbam的检测，检出限为0.12和0.003 ppm，R ²分别为0.988和0.9821，回收率分别为88–103％和87.2–103.5％，相对标准偏差分别为4.1–9.2％和3.5–8.3％。因此，当前的简单而绿色的方法可用于将来的研究中检测其他不安全的化学物质。