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Haloperidol-based conditioned increase in locomotor activity is disrupted by latent inhibition and extended interstimulus interval.
Pharmacology Biochemistry and Behavior ( IF 3.3 ) Pub Date : 2020-09-03 , DOI: 10.1016/j.pbb.2020.173036
Luis Gonzalo De la Casa 1 , Lucía Cárcel 1 , Mélanie Marias 1 , Juan Carlos Ruiz-Salas 1
Affiliation  

Previous research have shown that repeated administration of 0.5 mg/kg of haloperidol in a given context gives rise to an increase in activity when spontaneous locomotor activity is recorded in a drug-free test conducted in such context. In order to confirm whether this type of response is based on processes of a Pavlovian nature, we conducted two experiments involving two manipulations that disrupt conditioning in typical classical conditioning procedures: preexposure of the to-be-conditioned stimulus (latent inhibition), and an increase in the length of the inter-stimulus interval. The results revealed that both manipulations were effective in reducing the conditioned increase of the locomotor response. This kind of conditioning can be explained in terms of the differential effects of low vs. high doses of haloperidol, and the temporal dynamics of conditioned response.



中文翻译:

基于氟哌啶醇的运动活动性条件性增加被潜在的抑制作用和延长的刺激间隔所干扰。

先前的研究表明,在这种情况下进行的无药物测试中记录了自发运动功能时,在给定情况下重复给药0.5 mg / kg的氟哌啶醇会增加活性。为了确认这种反应是否是基于巴甫洛夫式的过程,我们进行了两个实验,涉及两个操作,这些操作会破坏典型的经典条件程序中的条件:预先暴露要条件的刺激(潜在抑制)和刺激间隔的长度增加。结果表明,两种操作均可有效减少运动反应的条件性增加。可以用低剂量与高剂量氟哌啶醇的不同作用来解释这种条件,

更新日期:2020-09-09
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