当前位置: X-MOL 学术Environ. Toxicol. Pharmacol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Toxic effects of the food additives titanium dioxide and silica on the murine intestinal tract: Mechanisms related to intestinal barrier dysfunction involved by gut microbiota.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-09-03 , DOI: 10.1016/j.etap.2020.103485
Jun Yan 1 , Degang Wang 2 , Kang Li 1 , Qi Chen 1 , Wenqing Lai 1 , Lei Tian 1 , Bencheng Lin 1 , Yizhe Tan 1 , Xiaohua Liu 1 , Zhuge Xi 1
Affiliation  

This study aimed to compare the effects of three food-grade particles (micro-TiO2, nano-TiO2, and nano-SiO2) on the murine intestinal tract and to investigate their potential mechanisms of action. A 28-day oral exposure murine model was established. Samples of blood, intestinal tissues and colon contents were collected for detection. The results showed that all three particles could cause inflammatory damage to the intestine, with nano-TiO2 showing the strongest effects. Exposure also led to changes in gut microbiota, especially mucus-associated bacteria. Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signalling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.



中文翻译:

食品添加剂二氧化钛和二氧化硅对小鼠肠道的毒性作用:与肠道菌群参与的肠屏障功能障碍有关的机制。

这项研究旨在比较三种食品级颗粒(micro-TiO 2,nano-TiO 2和nano-SiO 2)对小鼠肠道的影响,并研究其潜在的作用机理。建立了28天的口腔暴露小鼠模型。收集血液,肠组织和结肠内容物样品进行检测。结果表明,这三种颗粒均会导致肠炎性损害,其中纳米TiO 2显示最强的效果。暴露也导致肠道微生物群,尤其是粘液相关细菌的改变。我们的结果表明,对肠道的毒性作用是由于肠道粘液屏障功能的降低和代谢脂多糖的增加,从而激活了下游炎症因子的表达。在暴露于纳米TiO 2的小鼠中,肠道PKC / TLR4 /NF-κB信号通路被激活。这些发现将提高人们对与食品级TiO 2和SiO 2使用相关的毒性的认识。

更新日期:2020-09-12
down
wechat
bug