OBJECTIVE To explore the relationship between fatigue, standard electrophysiological parameters and number and size of functioning motor units in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS Experienced fatigue was assessed using the linearly-weighted, modified Rasch-built fatigue severity scale (R-FSS) and the multidimensional Checklist of Individual Strength (CIS). Averaged electrophysiology values were calculated from multiple nerves. Motor Unit Number Index (MUNIX) technique was utilised to assess motor unit function. Assessments were repeated in 15 patients receiving regular intravenous immunoglobulin therapy, with changes in parameters calculated. RESULTS R-FSS and CIS scores did not correlate MUNIX or MUSIX sum scores from 3 different muscles. Inverse correlation was observed only between distal CMAP area and R-FSS but not CIS scores. However, changes in distal CMAP area and R-FSS scores on repeat assessment were not correlated. CONCLUSIONS Experienced fatigue does not appear to correlate with loss of functioning motor units in patients with CIDP. Changes in experienced fatigue on repeat assessment did not correlate with changes in any of the electrophysiological parameters, suggesting fatigue experienced in CIDP is not strongly correlated with peripheral nerve dysfunction. SIGNIFICANCE Nerve conduction studies and MUNIX values do not appear to be useful surrogate markers for fatigue in CIDP.

中文翻译：

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慢性炎性脱髓鞘性多发性神经病患者与疲劳相关的外周神经电生理学研究

目的探讨慢性炎症性脱髓鞘性多发性神经病（CIDP）患者疲劳、标准电生理参数与功能性运动单位数量和大小的关系。方法 使用线性加权、修正的 Rasch 建立的疲劳严重程度量表 (R-FSS) 和个人力量多维检查表 (CIS) 评估经历的疲劳。从多个神经计算平均电生理值。运动单位数指数（MUNIX）技术被用来评估运动单位功能。对 15 名接受常规静脉注射免疫球蛋白治疗的患者进行了重复评估，并计算了参数的变化。结果 R-FSS 和 CIS 分数与来自 3 种不同肌肉的 MUNIX 或 MUSIX 总分无关。仅在远端 CMAP 区域与 R-FSS 之间观察到负相关，而未在 CIS 评分之间观察到负相关。然而，远端 CMAP 区域的变化和重复评估的 R-FSS 分数不相关。结论 在 CIDP 患者中，经历的疲劳似乎与功能性运动单位的丧失无关。重复评估中经历的疲劳变化与任何电生理参数的变化无关，表明 CIDP 中经历的疲劳与周围神经功能障碍没有强相关性。意义 神经传导研究和 MUNIX 值似乎不是 CIDP 疲劳的有用替代指标。结论 在 CIDP 患者中，经历的疲劳似乎与功能性运动单位的丧失无关。重复评估中经历的疲劳变化与任何电生理参数的变化无关，表明 CIDP 中经历的疲劳与周围神经功能障碍没有强相关性。意义 神经传导研究和 MUNIX 值似乎不是 CIDP 疲劳的有用替代指标。结论 在 CIDP 患者中，经历的疲劳似乎与功能性运动单位的丧失无关。重复评估中经历的疲劳变化与任何电生理参数的变化无关，表明 CIDP 中经历的疲劳与周围神经功能障碍没有强相关性。意义 神经传导研究和 MUNIX 值似乎不是 CIDP 疲劳的有用替代指标。