mESCs can self-renew indefinitely in vitro. However, depending on culture conditions some strains are more unstable than others. In this issue of Cell Stem Cell, Skelly et al. (2020) and Ortmann et al. (2020) shed light into the role genetic variation plays in control of ground state pluripotency.

中文翻译：

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揭示不稳定性：遗传变异是mESC多能性变异的基础。

mESC可以在体外无限期自我更新。但是，根据培养条件，某些菌株比其他菌株更不稳定。在本期《细胞干细胞》中，Skelly等人。（2020）和Ortmann等。（2020）揭示了遗传变异在控制基态多能性中的作用。