Abnormal local spontaneous brain activity during the resting state has been observed in chronic obstructive pulmonary disease (COPD). However, it is still largely unclear whether the abnormalities are related to specific frequency bands. Our purpose was to explore intrinsic neural activity changes in different frequency bands by using the amplitude of low-frequency fluctuation (ALFF) method in stable COPD patients. Nineteen stable COPD patients and twenty gender-, age- and education-matched normal controls (NCs) underwent functional magnetic resonance imaging scans, cognitive function tests and lung function tests. Two different frequency bands (slow-4: 0.027–0.073 Hz; slow-5: 0.01–0.027 Hz) were calculated and analyzed for frequency-dependent intrinsic neural activity by using the ALFF method. A two-way analysis of variance test was used to compare the main effects of the groups and the frequency bands in the ALFF method. Further post-hoc t-tests were used to compare the differences between COPD patients and NCs in terms of the different frequency bands. A Pearson’s correlation analysis was performed to explore the relationship between the altered ALFF brain areas in the different frequency bands and the clinical evaluations in the COPD patients. There were main effects of the groups including significantly higher ALFF values in the right superior temporal gyrus (STG), the bilateral cerebellum posterior lobe (CPL), the right lingual gyrus (LG) and the right brainstem, and as well as significantly decreased ALFF values in the right inferior parietal lobule (IPL) and the angular. The main effect of frequency was demonstrated in the CPL, the STG, the prefrontal cortex and the middle cingulate gyrus. Furthermore, COPD patients exhibited more widespread alterations in intrinsic brain activity in the slow-5 band than in the slow-4 band. Moreover, the abnormal intrinsic brain activity in the slow-4 and slow-5 bands were associated with PaCO₂ in COPD patients. These current results indicated that COPD patients showed abnormal intrinsic brain activity in two different frequency bands, and abnormal intrinsic neuronal activity in different brain regions could be better detected by slow-5 band. These observations may provide a neoteric view into understanding the local neural psychopathology in stable COPD patients.

在慢性阻塞性肺疾病 (COPD) 中已观察到静息状态下异常的局部自发脑活动。然而，目前还不清楚这些异常是否与特定频段有关。我们的目的是通过使用低频波动幅度 (ALFF) 方法来探索稳定的 COPD 患者在不同频段内的内在神经活动变化。19 名稳定的 COPD 患者和 20 名性别、年龄和教育匹配的正常对照 (NC) 接受了功能性磁共振成像扫描、认知功能测试和肺功能测试。使用 ALFF 方法计算和分析了两个不同的频段（慢 4：0.027–0.073 Hz；慢 5：0.01–0.027 Hz）的频率依赖性内在神经活动。使用方差检验的双向分析来比较 ALFF 方法中的组和频带的主效应。进一步事后吨-tests用于比较COPD患者和NCs在不同频段方面的差异。进行 Pearson 相关分析以探讨不同频带中改变的 ALFF 脑区与 COPD 患者的临床评估之间的关系。各组的主要影响包括右侧颞上回（STG）、双侧小脑后叶（CPL）、右侧舌回（LG）和右侧脑干的ALFF值显着升高，以及ALFF值显着降低右侧顶下小叶 (IPL) 和角的值。频率的主要影响在 CPL、STG、前额叶皮层和中扣带回中得到证实。此外，COPD 患者在慢 5 波段表现出比慢 4 波段更广泛的内在大脑活动改变。此外，慢 4 和慢 5 波段的异常内在大脑活动与 PaCO 相关₂在 COPD 患者中。目前的这些结果表明，COPD患者在两个不同频段表现出异常的内在脑活动，慢5波段可以更好地检测不同脑区的异常内在神经元活动。这些观察结果可能为理解稳定型 COPD 患者的局部神经精神病理学提供新的视角。