We describe excessive buccal saliva (EBS) prevalence in patients with Parkinson’s Disease (PD) and controls of the COPARK study, its changes between “ON” and OFF” conditions and over time, its impact on Health-related Quality of life (HRQoL), and factors associated with this condition. We studied 671 ambulatory PD patients and 177 age/sex-matched controls. We defined “sialorrhea” as UPDRS item #6 (salivation) = 1 or 2; and “drooling” as item #6 = 3 or 4. SCOPA-Aut drooling score (item #2) was also available in a subset (45%) of the cohort. HRQoL was assessed by the PDQ-39 and SF-36 scales. Twenty-four months’ follow-up data were available in 401/671 patients. EBS as assessed by UPDRS was present in 38% of PD patients in the “ON” condition (“Sialorrhea”: 35%; “drooling”: 3%). There were also more PD patients reporting “drooling” than controls according to the SCOPA-Aut (49% vs 19%, p < 0.01). UPDRS salivation score was worse in the “OFF” vs “ON” condition in PD patients with motor fluctuations (0.90 ± 0.94 vs 0.54 ± 0.79, p < 0.01). UPDRS salivation score worsened after ~ 24 months of follow-up (0.47 ± 0.70 vs 0.64 ± 0.81, p < 0.01). Worse PDQ-39 scores were observed in PD patients with EBS in bivariate but not in multivariate analyses. EBS was directly related to PD duration and severity, male gender, dysphagia, hypomimia, and autonomic dysfunction (logistic regression). EBS was more frequent in PD patients than controls, worsened in the “OFF” condition and after ~ 24 months of follow-up, moderately affected HRQoL, and was correlated with indices of bradykinesia, dysphagia, and autonomic dysfunction.

我们描述了帕金森病 (PD) 患者和 COPARK 研究对照中过多的口腔唾液 (EBS) 流行率、其在“开”和“关”条件之间的变化以及随着时间的推移，其对健康相关生活质量 (HRQoL) 的影响，以及与这种情况相关的因素。我们研究了 671 名动态 PD 患者和 177 名年龄/性别匹配的对照。我们将“流涎”定义为 UPDRS 第 6 项（流涎）= 1 或 2；和“流口水”作为第 6 项 = 3 或 4。SCOPA-Aut 流口水评分（第 2 项）也可用于队列的子集 (45%)。HRQoL 由 PDQ-39 和 SF-36 量表评估。在 401/671 名患者中可获得 24 个月的随访数据。UPDRS 评估的 EBS 出现在 38% 处于“ON”状态的 PD 患者中（“流涎”：35%；“流口水”：3%）。p  < 0.01)。在有运动波动的 PD 患者中，在“OFF”与“ON”条件下，UPDRS 流涎评分更差（0.90 ± 0.94 vs 0.54 ± 0.79，p  < 0.01）。大约 24 个月的随访后，UPDRS 流涎评分恶化（0.47 ± 0.70 vs 0.64 ± 0.81，p  < 0.01）。在双变量分析中观察到 EBS PD 患者的 PDQ-39 评分更差，但在多变量分析中未观察到。EBS 与 PD 持续时间和严重程度、男性、吞咽困难、拟态减退和自主神经功能障碍（逻辑回归）直接相关。EBS 在 PD 患者中比对照组更常见，在“OFF”条件下恶化，随访约 24 个月后，HRQoL 受到中度影响，并且与运动迟缓、吞咽困难和自主神经功能障碍的指数相关。