Remodeling of the intracellular cytoskeleton plays a key role in accelerating tumor growth and metastasis. Targeting different cytoskeletal elements is important for existing and future anticancer therapies. Anillin is a unique scaffolding protein that interacts with major cytoskeletal structures, e.g., actin filaments, microtubules and septin polymers. A well-studied function of this scaffolding protein is the regulation of cytokinesis at the completion of cell division. Emerging evidence suggest that anillin has other important activities in non-dividing cells, including control of intercellular adhesions and cell motility. Anillin is markedly overexpressed in different solid cancers and its high expression is commonly associated with poor prognosis of patient survival. This review article summarizes rapidly accumulating evidence that implicates anillin in the regulation of tumor growth and metastasis. We focus on molecular and cellular mechanisms of anillin-dependent tumorigenesis that include both canonical control of cytokinesis and novel poorly understood functions as a nuclear regulator of the transcriptional reprogramming and phenotypic plasticity of cancer cells.

细胞内细胞骨架的重塑在加速肿瘤生长和转移中起着关键作用。针对不同的细胞骨架元素对于现有和未来的抗癌疗法非常重要。 Anillin 是一种独特的支架蛋白，可与主要细胞骨架结构（例如肌动蛋白丝、微管和隔膜聚合物）相互作用。这种支架蛋白的一个经过充分研究的功能是在细胞分裂完成时调节胞质分裂。新的证据表明，苯胺在非分裂细胞中具有其他重要活性，包括控制细胞间粘附和细胞运动。 Anillin 在不同的实体癌中显着过度表达，其高表达通常与患者生存的不良预后相关。这篇综述文章总结了迅速积累的证据，表明阿尼林参与肿瘤生长和转移的调节。我们专注于苯胺依赖性肿瘤发生的分子和细胞机制，包括胞质分裂的经典控制和作为癌细胞转录重编程和表型可塑性的核调节剂的新的知之甚少的功能。