The development of the vertebrate central nervous system (CNS) is tightly regulated by many highly conserved cell signalling pathways. These pathways ensure that differentiation and migration events occur in a specific and spatiotemporally restricted manner. Two of these pathways, Notch and Hedgehog (Hh) signalling, have been shown to form a complex web of interaction throughout different stages of CNS development. Strikingly, some processes employ Notch signalling to regulate Hh response, while others utilise Hh signalling to modulate Notch response. Notch signalling functions upstream of Hh response through controlling the trafficking of integral pathway components as well as through modulating protein levels and transcription of downstream transcriptional factors. In contrast, Hh signalling regulates Notch response by either indirectly controlling expression of key Notch ligands and regulatory proteins or directly through transcriptional control of canonical Notch target genes. Here, we review these interactions and demonstrate the level of interconnectivity between the pathways, highlighting context-dependent modes of crosstalk. Since many other developmental signalling pathways are active in these tissues, it is likely that the interplay between Notch and Hh signalling is not only an example of signalling crosstalk but also functions as a component of a wider, multi-pathway signalling network.

脊椎动物中枢神经系统（CNS）的发育受到许多高度保守的细胞信号通路的严格调控。这些途径确保分化和迁移事件以特定且时空限制的方式发生。其中两条通路，Notch 和 Hedgehog (Hh) 信号传导，已被证明在中枢神经系统发育的不同阶段形成复杂的相互作用网络。引人注目的是，一些过程利用 Notch 信号传导来调节 Hh 反应，而其他过程则利用 Hh 信号传导来调节 Notch 反应。 Notch 信号传导通过控制整合途径成分的运输以及调节下游转录因子的蛋白质水平和转录，在 Hh 反应的上游发挥作用。相比之下，Hh 信号传导通过间接控制关键 Notch 配体和调节蛋白的表达或直接通过典型 Notch 靶基因的转录控制来调节 Notch 反应。在这里，我们回顾这些相互作用并展示路径之间的互连水平，强调上下文相关的串扰模式。由于许多其他发育信号通路在这些组织中很活跃，因此 Notch 和 Hh 信号传导之间的相互作用可能不仅是信号串扰的一个例子，而且还充当更广泛的多通路信号网络的组成部分。