In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes using cat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formed in situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.

中文翻译：

---

TMSOTf 催化合成取代喹唑啉，使用六甲基二硅氮烷作为氮源在纯和微波辐照条件下。

在本文中，我们报道了一种高效且温和的合成路线，用于使用cat由官能化的 2-氨基二苯甲酮与各种苯甲醛构建取代的喹唑啉。TMSOTf 和六甲基二硅氮烷 (HMDS) 在纯净、无金属和微波辐照条件下原位形成气态氨。这种合成方案提供了所需的喹唑啉，其底物范围广泛，产率良好。通过 X 射线单晶衍射分析证实了一些结构。