To explore the influence of sodium ferulate (SF) on miR-133a and left ventricle remodeling (LVR) in rats with myocardial infarction (MI). The left coronary artery was ligated to create 36 ischemia-reperfusion (IR) rat models that were randomly divided into mock surgical group (MSG) (not ligated), model group (MG), and sodium ferulate group (SFG). After the successful modeling, SFG was intravenously injected with SF at the dose of 10 mg/kg, and the other two groups were injected with the same volume of normal saline. After 28 days, cardiac hemodynamic indices of all groups were measured; the myocardial infarction size (MIS), left ventricular mass index (LVMI), and collagen volume fraction (CVF) were calculated, the content of serum malondialdehyde (MDA) and activities of catalase (CAT), superoxide dismutase (SOD) and glutathione catalase (GSH-px) were detected by ELISA, and miR-133a expression in myocardial tissues of the left ventricle (LV) was detected by RT-qPCR. SF improved the cardiac hemodynamic indices of rat model and reduced the MIS, LVMI and CVF. SF decreased the serum MDA level and increased the serum CAT, SOD and GSH-px levels in rat model. SF increased the expression of miR-133a in myocardial tissue of rat model. Therefore, SF could effectively reduce the myocardial injury of IR rats and improve the LVR. Its mechanism may be related to the antioxygenation and upregulation of miR-133a.

探讨阿魏酸钠（SF）对心肌梗死（MI）大鼠miR-133a和左心室重构（LVR）的影响。结扎左冠状动脉建立缺血再灌注（IR）大鼠模型36只，随机分为模拟手术组（MSG）（未结扎）、模型组（MG）和阿魏酸钠组（SFG）。造模成功后,SFG按10 mg/kg的剂量静脉注射SF,其余两组注射等体积的生理盐水。28天后，测量各组心脏血流动力学指标；计算心肌梗死面积（MIS）、左心室质量指数（LVMI）、胶原体积分数（CVF），血清丙二醛（MDA）含量以及过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化氢酶活性采用ELISA法检测GSH-px，采用RT-qPCR检测左心室（LV）心肌组织中miR-133a的表达。SF改善大鼠模型心脏血流动力学指标，降低MIS、LVMI和CVF。SF 降低大鼠模型血清 MDA 水平，升高血清 CAT、SOD 和 GSH-px 水平。SF增加大鼠模型心肌组织中miR-133a的表达。因此，SF能有效减轻IR大鼠心肌损伤，提高LVR。其机制可能与miR-133a的抗氧合和上调有关。