Genetic Characteristics of HIV-1 CRF12_BF First Identified in Guangdong Province, China,AIDS Research and Human Retroviruses

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Genetic Characteristics of HIV-1 CRF12_BF First Identified in Guangdong Province, China
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2021-02-05 , DOI: 10.1089/aid.2020.0193
Yun Lan ₁ , Xiang He ₂ , Ruolei Xin ₃ , Linghua Li ₁ , Xuhe Huang ₂ , Xizi Deng ₁ , Xiaoping Tang ₁ , Weidong Jia ₁ , Weiping Cai ₁ , Fengyu Hu ₁

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Multiple HIV-1 genotypes were found circulating in Guangdong Province, China, as this province is located in South China and has a high frequency of international trade. In this study, we report the near full-length genome (NFLG) of CRF12_BF that was identified from a male patient in Guangzhou city, Guangdong Province; this is the first time CRF12_BF has been reported in mainland China. The NFLG was amplified, and then PCR products were sequenced by Sanger sequencing. The CRF12_BF strain was confirmed by the Basic Local Alignment Search Tool and a neighbor-joining phylogenetic tree. In addition, this CRF12_BF strain was confirmed to contain the non-nucleoside reverse transcriptase inhibitor mutation E138A associated with potential low-level resistance against efavirenz and low-level resistance against rilpivirine by the Stanford University HIV Drug Resistance Database program. The analyzed sequence data in this study will provide more information on the HIV epidemic in China.

更新日期：2021-02-10

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