Background. Hormonal changes had been found in menopausal women. Muscle and bone mass decline after menopause and with aging, increasing the risk for sarcopenia and osteoporosis in later life. Only a few studies suggest that menopausal hormonal changes have an effect on the decline in muscle mass. Objectives. This study aimed at evaluating the risk of muscle mass loss in menopausal women. Materials and Methods. Menopausal women from routine physical health examination were eligible for this study. Muscle mass was determined using dual-energy X-ray absorptiometry at baseline and 1 year later. All of the patients underwent the assessments for liver and kidney function, diabetes, and hypertension, and associated comorbidities were recorded. Results. A total of 172 patients were enrolled. 70 patients had muscle loss at 1 year, and the other 102 did not had loss. The mean age was years at the muscle loss group, while at the nonprogress group (). The mean body mass index was  kg/m² at the muscle loss group, while  kg/m² at the nonprogress group (). The baseline trunk limb fat mass ratio was in the muscle loss group and in the no muscle loss (). Using muscle mass loss as the outcome, logistical regression analysis showed that a baseline trunk limb mass ratio could predict muscle loss, and a higher baseline trunk limb mass ratio was associated with less muscle loss, while a lower trunk limb mass ratio was associated with increased muscle mass loss (). Conclusion. This is the first study to investigate the risk of muscle mass loss in menopausal women. Menopausal women with higher central fat had less muscle mass loss, while lower central fat was a risk factor for muscle mass loss. Chronic kidney disease was also a risk factor for muscle mass loss in menopausal women in this study.

中文翻译：

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降低中央脂肪会增加绝经期女性一年肌肉量减少的风险。

背景。在更年期妇女中发现了荷尔蒙变化。绝经后肌肉和骨量会随着年龄的增长而下降，从而增加晚年患肌肉减少症和骨质疏松症的风险。只有少数研究表明更年期荷尔蒙的变化对肌肉质量的下降有影响。目标。本研究旨在评估更年期妇女肌肉量减少的风险。材料和方法。常规身体健康检查的更年期妇女有资格参加本研究。在基线和 1 年后使用双能 X 射线吸收法测定肌肉质量。所有患者均接受了肝肾功能、糖尿病和高血压的评估，并记录了相关的合并症。结果. 共有 172 名患者入组。70 名患者在 1 年时出现肌肉丢失，另外 102 名患者没有丢失。平均年龄是年在肌肉损失组，而在非进展组（）。平均体重指数为 kg/m ²在肌肉损失组，而 kg/m ²在非进展组 (）。基线躯干肢体脂肪质量比为在肌肉损失组和在没有肌肉损失（）。以肌肉质量损失为结果，逻辑回归分析表明，基线躯干肢体质量比可以预测肌肉流失，较高的基线躯干肢体质量比与较少的肌肉流失相关，而较低的躯干肢体质量比与增加的肌肉质量损失（）。 结论。这是第一项调查更年期妇女肌肉质量损失风险的研究。具有较高中央脂肪的绝经期妇女的肌肉量减少较少，而较低的中央脂肪是肌肉量减少的危险因素。在这项研究中，慢性肾病也是绝经期妇女肌肉量减少的危险因素。