The evolutionary change of SARS-CoV-2 is of the outmost concern. With a more stable phenotype, mutation D614G has become dominant. Its structural impact prompts the development of an antibody that destabilizes the virus quaternary structure where it is most vulnerable. Vaccine-related antigenic regions are different from the proposed epitope, hence avoiding therapeutic redundancy.

中文翻译：

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SARS-CoV-2 优势 G614 菌株中刺突蛋白四级结构的治疗靶向失稳

SARS-CoV-2 的进化变化是最受关注的。具有更稳定的表型，突变 D614G 已成为显性。它的结构影响促进了一种抗体的开发，该抗体破坏了病毒最脆弱的四级结构。疫苗相关抗原区域与提议的表位不同，因此避免了治疗冗余。