Introduction: Thyroid isthmus is defined as the thin band connecting thyroid tissue between both lateral thyroid lobes. Recently, a possible association between thyroid nodules located in the isthmus and malignancy was proposed. The aim of this study was to compare the frequency of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories between nodules from the isthmus and nodules from both thyroid lobes. Methods: All fine needle aspiration cytology procedures performed between January 2016 and December 2019 at the Pathology Institute of Araçatuba, São Paulo, Brazil, were analyzed. For each nodule, at least 2 conventional slides were produced (1 stained by Giemsa and the other by hematoxylin and eosin). All cases were reported according to the TBSRTC. Clinical information (gender, age, and localization) and ultrasound data (size of nodules) were collected from medical requisition forms. To assess the association between the frequency of TBSRTC categories and nodule location, univariate analysis was performed using the χ² test or Fisher’s exact test, as appropriate. A p value #x3c;0.05 was considered statistically significant. Nodules located in transition between the isthmus and a right or left lobe were included in the isthmus group. Results: Considering the p value between the TBSRTC categories and thyroid nodule location, statistic association was not observed: nondiagnostic or unsatisfactory (p = 0.1442), atypia of undetermined significance or follicular lesion of undetermined significance (p = 0.3296), follicular neoplasm or suspicious for a follicular neoplasm (p = 0.0817), suspicious for malignancy (p = 0.8464), and malignant (p = 0.1082). Conclusion: In the studied population, nodules located in the isthmus were not related to any Bethesda System category.
Acta Cytologica

中文翻译：

---

细针穿刺细胞学的Bethesda系统类别与甲状腺结节位置无关：单一机构的经验。

简介：甲状腺峡部定义为连接甲状腺两侧叶之间的甲状腺组织的细带。最近，提出了峡部甲状腺结节与恶性肿瘤之间的可能联系。本研究的目的是比较峡部结节和两个甲状腺叶结节之间的Bethesda报告甲状腺细胞病理学（TBSRTC）类别的频率。方法：分析了2016年1月至2019年12月在巴西圣保罗的阿拉萨图巴病理研究所进行的所有细针穿刺细胞学检查程序。对于每个结节，至少产生2个常规玻片（1个被吉姆萨染色，另一个被苏木精和曙红染色）。根据TBSRTC报告了所有病例。从医疗申请表中收集临床信息（性别，年龄和位置）和超声数据（结节大小）。为了评估TBSRTC类别和结节位置的频率之间的关联，使用χ进行单变量分析²检验或Fisher精确检验，根据。一个p值＃x3c; 0.05被认为具有统计学意义。峡部组中包括位于峡部和右叶或左叶之间过渡的结节。结果：考虑到TBSRTC类别与甲状腺结节位置之间的p值，未观察到统计学关联：未诊断或不满意（p = 0.1442），意义不明的非典型性或意义不明的卵泡病变（p = 0.3296），滤泡性肿瘤或可疑对于滤泡性肿瘤（p = 0.0817），可疑恶性肿瘤（p = 0.8464）和恶性肿瘤（p = 0.1082）。结论：在研究人群中，位于峡部的结节与任何贝塞斯达系统类别都不相关。
细胞学学报