Binding of RNA to the gene expression regulator Polycomb repressive complex 2 (PRC2) has been proposed to antagonize PRC2’s chromatin recruitment. A new study now shows that RNA is in fact critical for correct recruitment of PRC2 at its target genes in human pluripotent stem cells and suggests that interplay of PRC2 and RNA can fine-tune PRC2’s regulatory role.

中文翻译：

---

RNA封闭了Polycomb圆。

RNA与基因表达调节剂的结合Polycomb Repressing Complex 2（PRC2）已被提议拮抗PRC2的染色质募集。现在一项新的研究表明，RNA实际上对于在人类多能干细胞中正确募集PRC2的靶基因至关重要，并且表明PRC2和RNA的相互作用可以调节PRC2的调节作用。