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Two new Zn(II) and Ni(II) coordination polymers: treatment effect on acute bacterial sinusitis by inhibiting the methicillin resistant Staphylococcus aureus growth
Inorganic and Nano-Metal Chemistry ( IF 1.4 ) Pub Date : 2020-09-02 , DOI: 10.1080/24701556.2020.1813763
Li-Ping Li 1 , Xue Jiang 1 , Lixiu Liu 2 , Xiao-Dong Hu 1
Affiliation  

Abstract

In this study, two new coordination polymers (CPs),{[(CH3)2NH2][Zn(FDA)(TZ)2]}n (1, H2FDA = furan-2,5-dicarboxyl acid, TZ = 1,2,3-triazole) and {[Ni2(H2O)3(HTTCA)]·H2O}n (2, H4TTCA = [1,1':2',1''-terphenyl]-3,3'',4',5'-tetracarboxylic acid), have been prepared under solvothermal conditions and characterized by single-crystal X-ray diffraction analyses successfully. Furthermore, the protective effect of the compounds in vitro and in vivo was evaluated. Firstly, the bacterial growth curves were measured after treatment with the compounds. Besides, the inflammatory cytokines in the blood was detected with enzyme linked immunosorbent assay (ELISA) detection kit.



中文翻译:

两种新型的Zn(II)和Ni(II)配位聚合物:通过抑制耐甲氧西林的金黄色葡萄球菌生长来治疗急性细菌性鼻窦炎

摘要

在这项研究中,两种新的配位聚合物(CPs){[(CH 32 NH 2 ] [Zn(FDA)(TZ)2 ]} n1,H 2 FDA =呋喃-2,5-二羧酸, TZ = 1,2,3-三唑)和{[Ni 2(H 2 O)3(HTTCA)]·H 2 O} n2,H 4 TTCA = [1,1':2',1'' -三苯基] -3,3'',4',5'-四羧酸)已在溶剂热条件下制备,并成功地通过单晶X射线衍射分析进行了表征。此外,化合物在体外体内的保护作用被评估。首先,用化合物处理后测量细菌生长曲线。此外,用酶联免疫吸附试验(ELISA)检测试剂盒可检测血液中的炎性细胞因子。

更新日期:2020-09-02
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