Abstract

In this study, two new coordination polymers (CPs),{[(CH₃)₂NH₂][Zn(FDA)(TZ)₂]}_n (1, H₂FDA = furan-2,5-dicarboxyl acid, TZ = 1,2,3-triazole) and {[Ni₂(H₂O)₃(HTTCA)]·H₂O}_n (2, H₄TTCA = [1,1':2',1''-terphenyl]-3,3'',4',5'-tetracarboxylic acid), have been prepared under solvothermal conditions and characterized by single-crystal X-ray diffraction analyses successfully. Furthermore, the protective effect of the compounds in vitro and in vivo was evaluated. Firstly, the bacterial growth curves were measured after treatment with the compounds. Besides, the inflammatory cytokines in the blood was detected with enzyme linked immunosorbent assay (ELISA) detection kit.

摘要

在这项研究中，两种新的配位聚合物（CPs）{[（CH ₃）₂ NH ₂ ] [Zn（FDA）（TZ）₂ ]} _n（1，H ₂ FDA =呋喃-2,5-二羧酸， TZ = 1,2,3-三唑）和{[Ni ₂（H ₂ O）₃（HTTCA）]·H ₂ O} _n（2，H ₄ TTCA = [1,1'：2'，1'' -三苯基] -3,3''，4'，5'-四羧酸）已在溶剂热条件下制备，并成功地通过单晶X射线衍射分析进行了表征。此外，化合物在体外和体内的保护作用被评估。首先，用化合物处理后测量细菌生长曲线。此外，用酶联免疫吸附试验（ELISA）检测试剂盒可检测血液中的炎性细胞因子。