Abstract

By applying the mixed-ligand approach, a new Cu(II)-based coordination polymer (CP) with the chemical formula of {[Cu(PMBD)(DPB)]·DPB}_n (1, where H₂PMBD is 3,3′-{[1,3-phenylenebis(methylene)]bis (oxy)}dibenzoic acid and DPB is 1,4-bis (pyridin-4-yl)benzene) have been successfully prepared using the solvothermal reaction conditions. CCK-8 assay and cell colony formation assay were performed to detect the inhibitory effect of compound on SW480 rectal cancer cells. The transwell assay was conducted to evaluate the inhibitory effect of compound on SW480 rectal cancer cells migration and invasion.

中文翻译：

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一种新的基于铜（II）的配位聚合物：结构测定和抗直肠癌活性

摘要

通过应用混合配体方法，化学式为{[Cu（PMBD）（DPB）]·DPB} _n（1，其中H ₂ PMBD为3的新的基于Cu（II）的配位聚合物（CP），使用溶剂热反应条件成功地制备了3'-{[[1,3-亚苯基双（亚甲基）]双（氧基）}二苯甲酸和DPB为1,4-双（吡啶-4-基）苯。进行CCK-8测定和细胞集落形成测定以检测化合物对SW480直肠癌细胞的抑制作用。进行transwell分析以评估化合物对SW480直肠癌细胞迁移和侵袭的抑制作用。