Drosophila melanogaster has proven to be an effective model system in uncovering both genetic and cellular contributions to human cancer. Many elusive genes and signaling pathways that control oncogenic growth were first identified using flies. In many cases, these discoveries were not driven by a direct search for novel genes involved in cancer but rather stemmed from research programs to uncover mechanisms that control growth and development. However, the bounty of genetic tools and the shared evolution of multicellular organisms places Drosophila in a powerful position to purposefully elucidate observations seen in human cancers. In the past decade, the role of antioxidants in cancer progression has shifted dramatically. This review highlights major findings driving this change in perspective and underscores an array of existing work and resources in laboratories using Drosophila that can make significant contributions to how the redox environment affects cancer progression.

中文翻译：

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果蝇如何告知抗氧化剂在癌症中的作用的新兴范式。

黑腹果蝇已被证明是揭示人类癌症的遗传和细胞贡献的有效模型系统。许多控制致癌生长的难以捉摸的基因和信号通路首先是使用果蝇鉴定的。在许多情况下，这些发现并非由直接寻找与癌症相关的新基因所驱动，而是源于发现控制生长和发育机制的研究计划。然而，丰富的遗传工具和多细胞生物的共同进化使果蝇处于有利地位，可以有目的地阐明人类癌症中的观察结果。在过去十年中，抗氧化剂在癌症进展中的作用发生了巨大变化。