Abstract

A new approach for the efficient and convenient synthesis of novel aminoalkyl-functionalized 4-arylquinolines via the Friedländer reaction of differently substituted 2-(3,4-dihydroisoquinolin-1-yl)anilines with various α-methylene ketones in acetic acid was developed. The reaction allows easy access to a diversity of 4-arylquinoline derivatives in moderate to excellent yields under mild conditions.

中文翻译：

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由Friedländer反应从2-（3,4-二氢异喹啉-1-基）苯胺合成氨基烷基官能化的4-芳基喹啉

摘要

提出了一种新的方法，通过乙酸中不同取代的2-（3,4-二氢异喹啉-1-基）苯胺与各种α-亚甲基酮的弗里德兰德反应，高效便捷地合成新型氨基烷基官能化的4-芳基喹啉。该反应允许在温和条件下以中等至优异的产率容易地获得多种4-芳基喹啉衍生物。