Intracellular reactive oxygen species (ROS) induced by receptor activator of NF‐kB ligand (RANKL) has been proven to be a critical factor in the development of osteoclasts. This study aimed to prove that schisandrin A (Sch), a novel anti‐oxidant compound, is able to suppress osteoclastogenesis and prevent bone loss in ovariectomized (OVX) mice by suppressing ROS via nuclear factor erythroid 2‐related factor (Nrf2).

中文翻译：

---

五味子A通过抑制活性氧和激活Nrf2信号抑制破骨细胞生成

由 NF-kB 配体受体激活剂 (RANKL) 诱导的细胞内活性氧 (ROS) 已被证明是破骨细胞发育的关键因素。本研究旨在证明五味子 A (Sch) 是一种新型抗氧化化合物，能够通过核因子红细胞 2 相关因子 (Nrf2) 抑制 ROS，从而抑制破骨细胞生成并防止卵巢切除 (OVX) 小鼠的骨质流失。