Dopamine neurons in the ventral periaqueductal gray modulate isoflurane anesthesia in rats.,CNS Neuroscience & Therapeutics

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Dopamine neurons in the ventral periaqueductal gray modulate isoflurane anesthesia in rats.
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2020-09-02 , DOI: 10.1111/cns.13447
Chengxi Liu _{1,

2} , Xiao Zhou ₂ , Qiuyu Zhu ₂ , Bao Fu _{1,

3} , Song Cao ₁ , Yu Zhang _{1,

2} , Lin Zhang _{1,

2} , Yi Zhang _{1,

4} , Tian Yu _{1,

2}

Affiliation

General anesthesia has been applied in surgery for more than 170 years, and there is little doubt that GABA_A receptors have an important role as anesthetic molecular targets, but its neural mechanisms remain unclear. Increasing researchers have shown that dopaminergic pathways in the brain are crucial for sleep and wake. General anesthesia‐induced unconsciousness and natural sleep share some neural correlates. However, the role of GABA_A receptors in ventral periaqueductal gray (vPAG) dopamine (DA) neurons in the isoflurane‐induced unconsciousness has yet to be identified.

中文翻译：

腹侧导水管周围灰质中的多巴胺神经元调节大鼠的异氟醚麻醉。

全身麻醉应用于外科手术已有170多年的历史，GABA _A受体作为麻醉分子靶点无疑具有重要作用，但其神经机制尚不清楚。越来越多的研究人员表明，大脑中的多巴胺能通路对睡眠和觉醒至关重要。全身麻醉引起的无意识和自然睡眠有一些神经相关性。然而，GABA _A受体在异氟醚诱导的无意识中腹侧导水管周围灰质 (vPAG) 多巴胺 (DA) 神经元中的作用尚未确定。

更新日期：2020-10-17

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