BACKGROUND Astaxanthin ester (Asta-E) is used as functional nutraceuticals in many food products. Unfortunately, Asta-E utilization is currently limited owing to its chemical instability and low bioavailability. The purpose of this study is to investigate the promotion effect of oil matrixes on the stability, antioxidant activity, bioaccessibility and bioavailability of Asta-E. RESULTS The results showed that the stability of Asta-E in six oil matrixes was improved. Based on the DPPH radical scavenging activity experiment, the antioxidant activity of Asta-E was positively correlated with the degree of unsaturation of the oil matrixes, but not with the side chain length. The in vitro gastrointestinal tract (GIT) simulation model and in vivo experiment using mice were also employed to investigate the digestion and absorption characteristics of Asta-E in various oil matrixes. The results demonstrated that the bioaccessibility and bioavailability of Asta-E increased with the increase of fatty acid chain length of oil matrixes (oleate-TG > caprylate-TG > butyrate-TG), as well as with the decrease of unsaturation degree (olive oil > corn oil > fish oil). CONCLUSION Monounsaturated fatty acids (MUFA) and long-chain triglyceride (LCT) in an oil matrix were the factors that could efficiently improve the bioavailability of Asta-E. Moreover, the size of the mixed micelles of Asta-E during digestion was the main factor influencing the bioaccessibility of Asta-E. This study provides references for the design of suitable oil matrixes for Asta-E. This article is protected by copyright. All rights reserved.

中文翻译：

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油基质对虾青素酯稳定性、抗氧化活性、生物可及性和生物利用度的影响

背景虾青素酯（Asta-E）在许多食品中用作功能性营养品。不幸的是，由于其化学不稳定性和低生物利用度，Asta-E 的利用目前受到限制。本研究的目的是研究油基质对 Asta-E 的稳定性、抗氧化活性、生物可及性和生物利用度的促进作用。结果 结果表明，Asta-E 在六种油基质中的稳定性得到提高。基于DPPH自由基清除活性实验，Asta-E的抗氧化活性与油基质的不饱和度呈正相关，与侧链长度无关。还采用体外胃肠道(GIT)模拟模型和小鼠体内实验研究了Asta-E在各种油基质中的消化吸收特性。结果表明，随着油基质脂肪酸链长的增加（油酸-TG>辛酸-TG>丁酸-TG），以及不饱和度（橄榄油）的降低，Asta-E的生物可及性和生物利用度增加。 > 玉米油 > 鱼油）。结论油基质中的单不饱和脂肪酸（MUFA）和长链甘油三酯（LCT）是可以有效提高Asta-E生物利用度的因素。此外，消化过程中 Asta-E 混合胶束的大小是影响 Asta-E 生物可及性的主要因素。本研究为Asta-E适宜油基的设计提供参考。本文受版权保护。版权所有。