Internal biliary stenting during biliary reconstruction in liver transplantation decrease anastomotic biliary complications. Implantation of a resorbable internal biliary stent (RIBS) is interesting since it would avoid an ablation gesture. The objective of present work was to evaluate adequacy of selected PLA‐b‐PEG‐b‐PLA copolymers for RIBS aimed to secure biliary anastomose during healing and prevent complications, such as bile leak and stricture. The kinetics of degradation and mechanical properties of a RIBS prototype were evaluated with respect to the main bile duct stenting requirements in liver transplantation. For this purpose, RIBS degradation under biliary mimicking solution versus standard phosphate buffer control solution was discussed. Morphological changes, mass loss, water uptake, molecular weight, permeability, pH variations, and mechanical properties were examined over time. The permeability and mechanical properties were evaluated under simulated biliary conditions to explore the usefulness of a PLA‐b‐PEG‐b‐PLA RIBS to secure biliary anastomosis. Results showed no pH influence on the kinetics of degradation, with degradable RIBS remaining impermeable for at least 8 weeks, and keeping its mechanical properties for 10 weeks. Complete degradation is reached at 6 months. PLA‐b‐PEG‐b‐PLA RIBS have the required in vitro degradation characteristics to secure biliary anastomosis in liver transplantation and envision in vivo applications.

中文翻译：

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用于肝移植的可生物降解 PLA-PEG-PLA 内胆管支架的评估：体外降解和机械性能。

肝移植胆道重建期间的胆道内支架可减少吻合口胆道并发症。植入可吸收内胆管支架 (RIBS) 很有趣，因为它可以避免消融动作。目前工作的目的是评估所选 PLA -b- PEG- b的充分性用于 RIBS 的 ‐PLA 共聚物旨在在愈合过程中确保胆道吻合并防止并发症，例如胆漏和狭窄。RIBS 原型的降解动力学和机械性能根据肝移植中主要胆管支架的要求进行了评估。为此目的，讨论了胆汁模拟溶液与标准磷酸盐缓冲液对照溶液下的 RIBS 降解。随着时间的推移，检查了形态变化、质量损失、吸水率、分子量、渗透性、pH 变化和机械性能。在模拟胆道条件下评估渗透性和机械性能，以探索PLA- b -PEG- b的有用性‐PLA RIBS 以确保胆道吻合。结果表明，pH 对降解动力学没有影响，可降解的 RIBS 保持不渗透性至少 8 周，并保持其机械性能 10 周。在 6 个月时达到完全降解。PLA- b-PEG-b - PLA RIBS具有所需的体外降解特性，以确保肝移植中的胆道吻合和设想体内应用。