Keeping tracts on track: The FimH adhesion protein has long been identified a potential therapeutic target for UPEC‐induced UTIs. As such, a substantial body of research has been conducted into the development of a mannose‐based FimH antagonist. Herein, we discuss the rationale behind this targeting approach and the three main categories of mannose‐based FimH inhibitors.

中文翻译：

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基于甘露糖治疗尿路致病性大肠杆菌引起的尿路感染的进展

保持肠道正常运转：FimH 粘附蛋白长期以来一直被认为是 UPEC 诱导的尿路感染的潜在治疗靶点。因此，人们对基于甘露糖的 FimH 拮抗剂的开发进行了大量研究。在此，我们讨论了这种靶向方法背后的基本原理以及基于甘露糖的 FimH 抑制剂的三个主要类别。