The object of this work is to investigate the effects of emodin and curcumin on Pengze crucian carp. Fish was, respectively, fed Control diet and supplementation of 50 mg/kg emodin (EM group) and curcumin (CU group) with 4 repetitions each group (20 fish per cage). Our results indicated that the growth was unaffected by diets, whilst whole‐body lipid content was detected to remarkably decrease in EM group. Two additives exerted positive impacts on antioxidant system through elevation of antioxidant enzymes activities and antioxidants content. The improvement of intestinal antioxidant property appeared to be associated with up‐regulating expression of antioxidant genes through nuclear factor erythroid 2‐related factor 2 (Nrf2) activation. Moreover, intestinal inflammatory response was suppressed in EM and CU groups through inhibition of Toll‐like 4 receptor (TLR4) signalling pathway and pro‐inflammatory cytokine genes expression, and it may be related to the regulation of antioxidant system and overexpression of interleukin‐10. Afterwards, intestinal barrier function was enhanced in EM and CU groups by inducing the expression of tight junction protein genes. These results revealed that emodin and curcumin exerted positive benefits on the health of Pengze crucian carp by enhancing antioxidant capacity, suppressing inflammatory response and improving intestinal barrier function.

中文翻译：

---

大黄素和姜黄素的补充对彭泽cru鱼抗氧化防御反应，炎症反应和肠屏障的有益作用

这项工作的目的是研究大黄素和姜黄素对彭泽cru鱼的影响。分别给鱼类喂食对照饮食和补充50 mg / kg大黄素（EM组）和姜黄素（CU组），每组重复4次（每笼20条鱼）。我们的结果表明，生长不受饮食的影响，而EM组的全身脂质含量显着下降。两种添加剂通过提高抗氧化酶的活性和抗氧化剂的含量，对抗氧化系统产生了积极的影响。肠道抗氧化特性的改善似乎与通过核因子红系2相关因子2（Nrf2）激活上调抗氧化基因的表达有关。此外，EM和CU组的肠道炎性反应通过抑制Toll-like 4受体（TLR4）信号通路和促炎性细胞因子基因表达而得到抑制，这可能与抗氧化系统的调节和白介素10的过表达有关。此后，通过诱导紧密连接蛋白基因的表达，EM和CU组的肠屏障功能得到增强。这些结果表明，大黄素和姜黄素通过增强抗氧化能力，抑制炎症反应和改善肠屏障功能，对彭泽cru鱼的健康产生积极的好处。通过诱导紧密连接蛋白基因的表达，EM和CU组的肠屏障功能得到增强。这些结果表明，大黄素和姜黄素通过增强抗氧化能力，抑制炎症反应和改善肠屏障功能，对彭泽cru鱼的健康产生积极的好处。通过诱导紧密连接蛋白基因的表达，EM和CU组的肠屏障功能得到增强。这些结果表明，大黄素和姜黄素通过增强抗氧化能力，抑制炎症反应和改善肠屏障功能，对彭泽cru鱼的健康产生积极的好处。