Gastroesophageal reflux disease (GERD) is a common clinical condition for which our understanding has evolved over the past decades. It is now considered a cluster of phenotypes with numerous anatomical and physiological abnormalities contributing to its pathophysiology. As such, it is important to first understand the underlying mechanism of the disease process for each patient before embarking on therapeutic interventions. The aim of our paper is to highlight the mechanisms contributing to GERD and review investigations and interpretation of these results. Finally, the paper reviews the available treatment modalities for this condition, ranging from medical intervention, endoscopic options through to surgery and its various techniques.

中文翻译：

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重新思考胃食管反流病

胃食管反流病 (GERD) 是一种常见的临床疾病，我们的理解在过去几十年中不断发展。它现在被认为是一组表型，具有许多导致其病理生理学的解剖学和生理学异常。因此，在开始治疗干预之前，首先了解每位患者疾病过程的潜在机制非常重要。我们论文的目的是强调导致 GERD 的机制，并审查对这些结果的调查和解释。最后，本文回顾了针对这种情况的可用治疗方式，从医疗干预、内窥镜选择到手术及其各种技术。