Drug-resistant focal epilepsy (DRFE) in children can impair cognition and behavior, and lead to premature death. Increased pediatric epilepsy surgery numbers reflect the improvements in seizure control and long-term developmental outcomes. Yet, many children with DRFE are not candidates for surgical resection due to overlap of the seizure network with eloquent cortex or multiple seizure-onset zones, making surgery dangerous or ineffective. In adults, responsive neurostimulation (RNS System) therapy is safe and effective treatment for DRFE with one or two seizure foci, especially when the seizure focus is in eloquent cortex. We present six pediatric patients with DRFE who underwent RNS implantation. Our outcomes demonstrate safety, decreased clinical seizure frequency, as well as improved functional status and quality of life. Changes in the clinical seizure semiology and frequency occurred in conjunction with adjustments to the stimulation parameters, supporting the efficacy of responsive neuromodulation in children.

中文翻译：

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儿科难治性癫痫的反应性神经刺激：单中心经验

儿童耐药性局灶性癫痫 (DRFE) 会损害认知和行为，并导致过早死亡。小儿癫痫手术数量的增加反映了癫痫发作控制和长期发育结果的改善。然而，由于癫痫网络与雄辩皮质或多个癫痫发作区重叠，许多患有 DRFE 的儿童不适合手术切除，使手术变得危险或无效。在成人中，反应性神经刺激（RNS 系统）疗法是治疗 DRFE 的安全有效的治疗方法，有 1 或 2 个癫痫病灶，尤其是当癫痫病灶位于雄辩皮层时。我们介绍了六名接受 RNS 植入的 DRFE 儿科患者。我们的结果证明了安全性、临床癫痫发作频率降低以及功能状态和生活质量的改善。