A673T mutation in the amyloid precursor protein (APP) is a rare variant associated with a reduced risk of late-onset Alzheimer‘s disease (AD) and age-related cognitive decline. The A673T mutation decreases beta-amyloid (Aβ) production and aggregation in neuronal cultures in vitro. Here we have identified a Finnish non-diseased male individual carrying a heterozygous A673T mutation, obtained a skin biopsy sample from him, and generated an iPSC line using commercially available integration-free Sendai virus-based kit. The established iPSC line retained the mutation, expressed pluripotency markers, had a normal karyotype, and differentiated into all three germ layers in vitro.

淀粉样蛋白前体蛋白（APP）中的A673T突变是罕见的变异，与晚期阿尔茨海默氏病（AD）和与年龄有关的认知能力下降的风险降低有关。A673T突变可降低体外神经元培养物中β淀粉样蛋白（Aβ）的产生和聚集。在这里，我们确定了一个带有杂合性A673T突变的芬兰未患病男性，从他那里获得了皮肤活检样本，并使用可商购的无整合仙台病毒的试剂盒生成了iPSC品系。已建立的iPSC系保留了该突变，表达了多能性标记，具有正常的核型，并在体外分化为所有三个胚层。