Sesamin, a major lignin isolated from sesame (Sesamum indicum) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro, and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.

芝麻素是从芝麻 ( Sesamum indicum ) 种子和芝麻油中分离出来的主要木质素，已知具有抗氧化和抗炎特性。多项研究表明，氧化应激和炎症在多种心血管疾病 (CVD) 中发挥着重要作用。这篇综合综述总结了芝麻素对 CVD 及其危险因素影响的证据，主要是由于其抗氧化特性。具体而言，本综述重点介绍了芝麻素在体内和体外的抗高血压、抗动脉粥样硬化、抗血栓、抗糖尿病、抗肥胖、脂肪分解作用的潜在机制，并确定了芝麻素和芝麻素靶向的信号通路。它的代谢物。数据表明，RAS/MAPK、PI3K/AKT、ERK1/2、p38、p53、IL-6、TNFα 和 NF-κB 信号网络均参与调节芝麻素对 CVD 及其危险因素的各种影响。总之，表明芝麻素可以降低 CVD 风险的实验证据是令人信服的。因此，芝麻素可作为辅助治疗剂来对抗 CVD 及其多种危险因素。