In this diffusion tensor imaging study, we explored the associations of body mass index (BMI) with white matter microstructure in first-episode schizophrenia spectrum disorder patients (n = 69) versus healthy controls (n = 93). We focused on fractional anisotropy (FA) measures for fronto-limbic white matter tracts known to connect brain regions which form part of a "core eating network". Secondary objectives included the associations of body mass with global illness severity, psychopathology and depressive symptoms. In a multivariate analysis of covariance (MANCOVA) model, there was a significant interaction between BMI and group (patient versus control) across the fronto-limbic white matter tracts of interest (F(1,155)= 4.91, p = 0.03). In a sub-analysis, BMI was significantly inversely correlated with FA measures for the genu and body of the corpus callosum, left and right tapetum, and left superior fronto-occipital fasciculus in controls. In patients, BMI was significantly positively correlated with white matter FA for the genu of the corpus callosum and left tapetum. Lower BMI was significantly correlated with more severe negative symptoms, as was earlier age of illness onset. Body mass may be differentially associated with fronto-limbic white matter microstructure in first-episode schizophrenia spectrum disorder compared to controls.

中文翻译：

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与健康对照组相比，首发精神分裂症谱系障碍患者的额叶边缘白质分数各向异性和体重指数

在这项扩散张量成像研究中，我们探讨了首发精神分裂症谱系障碍患者 (n = 69) 与健康对照组 (n = 93) 的体重指数 (BMI) 与白质微结构的关联。我们专注于额叶边缘白质束的分数各向异性 (FA) 测量，这些白质束已知连接构成“核心饮食网络”一部分的大脑区域。次要目标包括体重与全球疾病严重程度、精神病理学和抑郁症状的关联。在协方差的多变量分析 (MANCOVA) 模型中，BMI 和组（患者与对照组）在额叶边缘白质感兴趣区域之间存在显着的交互作用（F（1,155）= 4.91，p = 0.03）。在子分析中，BMI 与对照组的胼胝体膝部和体部、左右绒毡层以及左侧额枕上束的 FA 测量值显着负相关。在患者中，BMI与胼胝体膝部和左侧绒毡层的白质FA显着正相关。较低的 BMI 与更严重的阴性症状显着相关，发病年龄较早也是如此。与对照组相比，在首发精神分裂症谱系障碍中，体重可能与额叶边缘白质微结构存在差异。较低的 BMI 与更严重的阴性症状显着相关，发病年龄较早也是如此。与对照组相比，在首发精神分裂症谱系障碍中，体重可能与额叶边缘白质微结构存在差异。较低的 BMI 与更严重的阴性症状显着相关，发病年龄较早也是如此。与对照组相比，在首发精神分裂症谱系障碍中，体重可能与额叶边缘白质微结构存在差异。