The analysis of cardiac wall stress is of importance to understand the development of heart failure (HF). The aim of the study is to carry out the cardiac mechanics analysis to show the changes of left ventricular (LV) wall stresses after LV hypertrophy (LVH) and myocardial infarction (MI). Here, LVH and MI were generated in rabbit hearts through the transverse aortic constriction (TAC) and the distal left circumflex (LCx) artery ligation operations, respectively. Physiological and CT measurements were carried out at postoperative 2 and 4 weeks, based on which a finite element (FE) model was developed to perform the mechanics computation. We found a gradual increase of end-diastolic myofiber stress in free wall and interventricular septum of LVH and MI (higher stress in the free wall than the septum). In the interventricular septum, the 4-weeks LVH group has the highest ED myofiber stresses (11.378±3.022 kPa), while the 4-weeks MI group has the highest ED myofiber stresses (13.494±2.835 kPa) in the free wall. LVH increased myocardial volume (3.49±0.07 and 4.52±0.26 ml at postoperative 2 and 4 weeks) while MI increased LV volume (from 2.75±0.29 to 4.19±0.27 ml). LVH and MI had different distributions of local myofiber stress.

心脏壁应力的分析对于了解心力衰竭（HF）的发展非常重要。该研究的目的是进行心脏力学分析，以显示左心室肥大（LVH）和心肌梗塞（MI）后左心室（LV）壁应力的变化。在这里，LVH和MI分别通过横断主动脉缩窄（TAC）和远端左回旋支（LCx）动脉结扎手术在兔心脏中产生。术后2周和4周进行生理和CT测量，在此基础上开发了有限元（FE）模型以进行力学计算。我们发现LVH和MI的自由壁和室间隔中舒张末期肌纤维的应力逐渐增加（自由壁中的应力高于隔膜）。在室间隔内 LVH组4周的ED肌纤维应力最高（11.378±3.022 kPa），而MI组4周的自由壁的ED肌纤维应力最高（13.494±2.835 kPa）。LVH增加了心肌体积（术后2和4周时为3.49±0.07和4.52±0.26 ml），而MI增加了LV体积（从2.75±0.29到4.19±0.27 ml）。LVH和MI具有不同的局部肌纤维应力分布。