The N-alkylation of amines constitutes one of the most widely applied transformations in synthetic chemistry, but established methods often utilise non-renewable feedstocks and must be adapted for a post fossil fuel world. This review is focused on emerging methodologies in which redox surrogate reagents to carbonyl compounds are used which may be more readily sourced from nature. The review considers both chemocatalytic and biocatalytic approaches and considers challenges such as application and the development of sustainable methodology with low carbon impact.

中文翻译：

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可持续胺N-烷基化的氧化还原替代方法

胺的N-烷基化反应是合成化学中应用最广泛的转化之一，但是已建立的方法通常利用不可再生的原料，必须适应后化石燃料世界。这篇综述集中在新兴的方法论上，其中使用的羰基化合物的氧化还原替代试剂可能更容易从自然界中获得。审查同时考虑了化学催化方法和生物催化方法，并考虑了诸如应用和开发低碳影响的可持续方法等挑战。