Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy, patient's survival post diagnosis remains short. A limitation for success in finding novel improved therapeutic options for such dismal disease partly lies in the lack of a relevant animal model that accurately recapitulates patient disease and standard of care. In the present study, we have developed an immunocompetent GBM model that includes tumor surgery and a radio/chemotherapy regimen resembling the Stupp protocol and we have used this model to test the impact of the pharmacological inhibition of the endoplasmic reticulum (ER) stress sensor IRE1, on treatment efficacy.

多形胶质母细胞瘤（GBM）是最严重的原发性脑癌。尽管包括外科手术切除和放射/化学疗法在内的积极治疗，患者的诊断后生存期仍然很短。成功找到针对这种疾病的新颖的改良治疗选择的局限性部分在于缺乏能准确概括患者疾病和护理标准的相关动物模型。在本研究中，我们开发了一种具有免疫功能的GBM模型，其中包括肿瘤手术和类似于Stupp方案的放射/化学疗法，并且我们已经使用该模型来测试药理学抑制内质网（ER）压力传感器IRE1的影响。 ，对治疗功效。