Traumatic spinal cord injury (SCI) can lead to motor disturbance, sensory deficit, or autonomic dysfunction. The role of circRNAs in the pivotal physiopathological processes of SCI has been demonstrated recently. However, no similar research has been performed to explore the circRNAs involved in apoptosis after SCI. The differentially expressed circRNAs in mice spinal cord three days after SCI were originally detected with microarray assay (n = 4/group). Subsequently, potential apoptosis-related circRNAs were predicted by comprehensive bioinformatics analysis. In total, 1131 circRNAs varied (>2-fold change, p < 0.05) in the injured mice spinal cord. The characters of these circRNAs were summarized. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was applied to predict the primary function of these circRNAs. 148 circRNAs were found to be correlated to the apoptosis injury progress in after SCI. Moreover, an apoptosis-related ceRNA network was constructed. In loss-of-function experiments, cicRNA.7079 knockdown enhanced apoptosis in NSC-34 motor neurons. This study may contribute to new insights into the mechanism of apoptosis after SCI. The anticipation of anti-apoptosis circRNA. 7079 may provide potential research targets for SCI in mice.

创伤性脊髓损伤 (SCI) 可导致运动障碍、感觉障碍或自主神经功能障碍。最近已经证明了 circRNA 在 SCI 的关键病理生理过程中的作用。然而，尚未进行类似的研究来探索参与 SCI 后细胞凋亡的 circRNA。SCI后三天小鼠脊髓中差异表达的circRNA最初是用微阵列分析检测到的（n = 4/组）。随后，通过综合生物信息学分析预测了潜在的凋亡相关 circRNA。总共有 1131 个 circRNA 变化（>2 倍变化，p< 0.05) 在受伤的小鼠脊髓中。总结了这些circRNA的特征。应用基因本体论 (GO) 和京都基因和基因组百科全书 (KEGG) 富集分析来预测这些 circRNA 的主要功能。发现148个circRNA与SCI后的细胞凋亡损伤进展相关。此外，还构建了一个凋亡相关的 ceRNA 网络。在功能丧失实验中，cicRNA.7079 敲低增强了 NSC-34 运动神经元的细胞凋亡。这项研究可能有助于对 SCI 后细胞凋亡机制的新见解。抗凋亡circRNA的预期。7079 可能为小鼠 SCI 提供潜在的研究靶点。